How does Joint Doctor work?


Joint Doctor® Collagen complex works by repairing damaged cartilage and almost completely stops further deterioration. Joint Doctor will also cause collagen producing cells in the body to increase their natural production of collagen up to levels only usually experience by those under 25 years of age.

What will this mean for the user?

A vastly improved range of mobility and greatly reduced pain levels.

Reduced pain levels, it must be full of painkillers. Is Joint Doctor® collagen complex dangerous?


No! Joint Doctor® Collagen Complex capsules are completely safe and contain only natural ingredients. Long term use of even non prescription analgesics has been shown in scientific studies to cause long term damage to vital internal organs. The pain relief that has been reported by thousands of satisfied Joint Doctor users is caused by the development of fresh new cartilage that naturally cushions your joints leading to smooth pain free joint movements.

Sounds too good to be true. Is there any scientific proof of its effects?


Yes! Joint Doctor's® primary active ingredient has been extensively researched and validated. Professor R Moskowitz, director of the Arthritis Institute, university of Cleveland, USA, conducted research on 300 osteoarthritis patients. The multi centered trials showed a significant reduction in pain and an improvement in Joint mobility in the group taking Joint Doctor® Collagen Complex. The researchers also investigated the effect of Joint Doctor Supplementation on the collagen producing cells in the body (chondrocytes) and indicated an increase in production of over 250%!

I use medication, can I still use Joint Doctor® collagen complex?


Yes! Joint Doctor® Collagen Complex is completely natural and free from any side effects and therefore will not react with most forms of medication, however, we strongly recommend that an assessment is made by a medical professional or doctor before anyone taking prescription medication, uses our formulation.

I don't suffer from osteoarthritis, but I do participate in sports regularly and often experience the painful effects of stiff joints. Will Joint Doctor® Collagen Complex benefit me?


Yes! Thousands of sportsmen and women regularly use Joint Doctor® Collagen Complex to naturally increase their production of joint cushioning collagen. Sports men and women using Joint Doctor have reported a much lower instance of joint stiffness and greater recovery from workouts. This injury preventative supplement will ensure your joints remain strong, supple and withstand the great demands that competitive exercise places on the body. There have been many reports of old, long standing injuries simply 'clearing up' with the regular use of Joint Doctor® Collagen Complex.

That sounds great! How many capsules do I need to take per day?


Take 1-2 capsules 3 times daily with a glass of water on an empty stomach. For optimum results do not take with any other protein powders/supplements. Wait 30 minutes before eating or take all 6 on an empty stomach before bedtime. A 5-10 gram daily dose taken over a 1-3 month period will dramatically replenish your natural collagen levels, leading to a number of welcome physical benefits.

Why take a collagen hydrolysate supplement?


The stress placed on our joints means that they are prone to damage in the longer term. Cartilage is worn out and sometimes even lost. Unfortunately the body is sometimes unable to product sufficient new cartilage to counteract this loss. By taking a collagen hydrolysate supplement we can provide our body with the essential building blocks needed for the formation of joint cartilage.
Collagen hydrolysate is used as a nutritional supplement for the prevention and treatment of degenerative diseases like osteoarthritis.

How quickly will I notice a difference?


Acute pain, morning stiffness and restriction of articular function are symptoms of degenerative diseases like osteoarthritis. Patients taking 5-10 grams of collagen hydrolysate per day see significant improvements after 6 to 12 weeks.
If taken preventatively, 5-10 grams of collagen hydrolysate per day will reduce the risk of degenerative disorders.

Why is collagen hydrolysate specifically important for cartilage in comparison to other proteins?


The amino acid composition of collagen hydrolysate corresponds exactly to that of collagen - the predominant protein in cartilage.

Does collagen hydrolysate have any other benefits?


As well as improving joint mobility people have reported a gain in hair thickness and quality of skin and nails.

Which persons can benefit from collagen hydrolysate?


Collagen hydrolysate is an ideal nutritional supplement for anyone wanting to stay fit and well or who want to reduce risks of degenerative joint disease by constitutional nutrition. Collagen hydrolysate administration has an important role for use in individuals at risk from the development of joint degeneration. Such at-risk populations include older individuals, particularly those individuals aged 50 years and older; individuals who are overweight; individuals whose occupational activities predispose to osteoarthritis, including jobs involving repeated knee-bending (e.g. carpenters, floor layers, and painters), textile workers, miners and dock workers; individuals participating in extensive non-occupational physical activities including recreational runners/walkers, cyclists, gardeners, soccer/football players; individuals with a past history of significant joint injury such as fracture or ligamentous injury; and individuals with a family history suggesting a genetic predisposition to osteoarthritis.

Basic questions on collagen and collagen hydrolysate


What is cartilage?


Cartilage is a tough, flexible tissue that consists of chondrocytes (cartilage cells) and matrix (collagen and proteoglycans).

What is collagen?


Collagen is the most abundant protein in the human and animal body representing 30% of total body protein. Collagen gives the structure to tendons, cartilage tissue, bones and connective tissue.
The collagen molecule is formed by 3 intertwined protein chains building a triple helix structure (with a molecular weight of ~300kD). The triple helix structure of collagen is responsible for the strength and flexibility of cartilage tissue.
The amino acid composition of collagen includes 30% glycine and 25% proline and hydroxyproline. These amino acids make collagen different from other proteins and are of great importance for collagen synthesis.

What is collagen hydrolysate?


Collagen hydrolysate is collagen (from skin, bone, cartilage) broken down by a natural process (hydrolysis) to facilitate easy absorption into the blood stream.
Since collagen hydrolysate has the same amino acid composition as collagen it is an ideal component for cartilage regeneration. Collagen hydrolysate stimulates collagen synthesis: this effect was proven by a laboratory study by Oesser et al. (Cell & Tissue Research 311:393-9; March 2003)
Clinical studies with patients suffering from osteoarthritis revealed the positive effect of collagen hydrolysate on joint health (e.g. pain reduction, reduced medication, improved physical function). The beneficial effect of collage hydrolysate on osteoarthritis is patented (European patent no. 0254289 Agents for the treatment of osteoarthritis, 1986, based on a study by Prof Adam.)
Collagen hydrolysate received GRAS status (Generally Recognised as Safe) by the US Food and Drug Administration (FDA).
Due to its special production process collagen hydrolysate does not set and is soluble in cold water.

What is the difference between collagen, collagen hydrolysate and gelatine?


Collagen is the most abundant protein in the human and animal body representing 30% of total body protein. Collagen gives structure to tendons, cartilage tissue, bones and connective tissue.
Gelatine is produced from collagen. It has gelling properties and is used in the food industry (e.g. as emulsifier, gel-former, taste and colour enhancer), in the pharmaceutical industry (e.g. for capsules, as blood replacement, agent for vitamin coating) and in the photo industry (e.g. as basis of film and photographic paper).
Collagen hydrolysate is also produced from collagen but by a different process. The amino acid compositions of collagen and collagen hydrolysate are very similar. This similarity gives collagen hydrolysate an important role in the build up of new cartilage. Research has shown that collagen hydrolysate stimulates collagen synthesis: this effect was proven by a laboratory study by Oesser et al. (Cell & Tissue Research 311:393-9; March 2003).
Clinical studies with patients suffering from osteoarthritis revealed the positive effect of collagen hydrolysate on joint health (e.g. pain reduction, reduced medication, improved physical function). The beneficial effect of collagen hydrolysate on osteoarthritis is patented (European patent No 0254289 Agents for the treatment of osteoarthritis, 1986, based on a study by Prof. Adam).
Collagen hydrolysate received GRAS status (Generally Recognised as Safe) by the US Food and Drug Administration (FDA).

What raw material is used?

How is collagen hydrolysate produced?


Collagen hydrolysate is extracted from the bovine or porcine material using a multi-state extraction process; it is then purified, concentrated, sterilized and dried. This results in cold water soluble powder of collagen hydrolysate.

When was the beneficial effect of collagen hydrolysate first discovered?
In the Middle Ages Saint Hildegard of Bingen (12th century; 1098-1179) described the beneficial effect of calf cartilage broth on joint pain.
Since 1980 scientists of different medical disciplines have strengthened their R&D activities in the field of both cartilage metabolism and the effect of collagen hydrolysate on joint health.

Has there been any research done on collagen hydrolysate?


There have been medical observations, key laboratory and clinical studies carried out over the past 20 years by internationally leading experts of different medical disciplines.
All clinical studies reveal positive effects of collagen hydrolysate on joint health, especially on osteoarthritis, for example:

In 1986, the beneficial effect of collagen hydrolysate on osteoarthritis was patented (European patent No 0254289 Agents for the treatment of osteoarthritis).
In spring 2003 Oesser et al published a laboratory study that could explain the potential basic mechanism of the clinical observations. Scientists were able to demonstrate that collagen hydrolysate stimulates collagen synthesis in cartilage cells (chondrocytes).

What are the most important studies on collagen hydrolysate?


Furthermore Prof. Roland Moskowitz, Director of the Arthritis Research Institute, Cleveland/USA conducted an international study (USA; UK; Germany) with 390 patients suffering from osteoarthritis.
The most extensive research was carried out by Prof. Milan Adam, Professor of Rheumatology at the University of Prague, which led to the issue of a European patent, No 0254289 Agents for the treatment of osteoarthritis.
Both studies reveal the positive effects of collagen hydrolysate on joint health, especially on osteoarthritis.
Dr Steffen Oesser, physiologist at the University of Kiel, Germany published key studies on cartilage metabolism and regeneration; his latest publication (Cell & Tissue Research 311: 393-9; March 2003) demonstrates the stimulatory effect of collagen hydrolysate on collagen biosynthesis.

How is collagen hydrolysate absorbed and how does it reach the cartilage?


Oesser et al. (Journal of Nutrition 129: 1891-95; 1999) conducted experiments with isolated segments of the intestine which have shown that collagen fragments can pass through the intestinal wall (10-15% of these proteins; in a high molecular form of up to 50kD) and reach the blood stream. Accumulation of radio-labelled collagen hydrolysate can subsequently be seen in cartilage.

What effects has collagen hydrolysate in cartilage?


Latest experiments by Oesser et al (Cell & Tissue Research 311:393-9; March 2003) demonstrated that collagen hydrolysate stimulates collagen biosynthesis in chondrocytes (cartilage cells). The presence of collagen hydrolysate leads to dose-dependent increase of collagen as found in cartilage.

What is osteoarthritis?

What is the standard therapy for osteoarthritis?


In spite of extensive research for decades osteoarthritis can still not be cured. Analgesics and anti-rheumatics only relieve pain or suppress the inflammation process and may have undesirable side effects. Therefore every new hope for the prevention and treatment of osteoarthritis must be carefully examined.

Questions on the administration of collagen hydrolysate


How is collagen hydrolysate taken?
5-10 grams of collagen hydrolysate should be taken daily over a period of at least three months.

How long will I need to take collagen hydrolysate?


Experts recommend a daily intake of 5-10 grams collagen hydrolysate for at least 3 months. Research shows that if you stop taking collagen hydrolysate altogether, the symptoms may reoccur. Therefore, once you have benefited from collagen hydrolysate, a maintenance dose taken every other day is recommended.

Can I take it when I am on other medication?


Yes, since collagen hydrolysate is just a food and not a pharmaceutical drug, there are neither contraindications nor side effects.